Kisspeptin
Peptides encoded by the KISS1 gene that act on the KISS1 receptor (GPR54), a key regulator of the reproductive hormone axis. Studied in human physiology research.
Level of evidence
Clinical trials — controlled human studiesWhat it is
Kisspeptins are a family of peptides (kisspeptin-54, -14, -13 and -10) cut from the same precursor, encoded by the KISS1 gene. They all share the same C-terminal end and bind the KISS1 receptor, also called GPR54. Check the certificate of analysis to know which form a batch contains.
State of the research
In 2003, mutations of GPR54 were linked to absent puberty, which made kisspeptin a major subject of reproductive endocrinology. It has since been given to volunteers and patients in research studies on the hormone axis; no medicine based on it is approved.
Sources
Last reviewed: October 2026
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