DSIP
A nine-amino-acid peptide isolated in 1977 from the blood of rabbits in induced sleep. Its role and mechanism are still debated.
Level of evidence
Early human data — small or uncontrolled studiesWhat it is
DSIP was isolated in 1977 by a team in Basel from the cerebral venous blood of rabbits whose sleep had been induced by electrical stimulation, which gave it its name. Its own receptor has not been identified.
State of the research
Small human studies were published in the 1980s and 1990s with inconsistent results. Its physiological function is still unclear.
Sources
Last reviewed: October 2026
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